Perioperative Antibiotic Prophylaxis in Orthognathic Surgery: a Clinical Trial
SUN Hao-Yun, Wu-Zhong-Xing, Yang-Xue-Wen
Division of Orthognathic Surgery and Plastic Surgery, Department of Oral and Maxillofacial Surgery, Key Laboratory of Oral Biomedical Engineering of Chinese Ministry of Education, Hospital and School of Stomatology, Wuhan University, Wuhan 430079, Hubei Province, China
Objective: The purpose of this study was to evaluate the efficacy of antibiotic prophylaxis in orthognathic surgery between different methods and conclude a proper one. Methods: To retrospectively analyze the infection results of selected 60 patients in orthognathic surgery, from April 2015 to April 2016． According to the hospitalization date and the application of antibiotics, the patients were divided into 2 groups． In group A, the period of hospitalization were from April 2015 to October 2015, and the postoperative antibiotics application lasted for 7 days until discharged. In group B, the period of hospitalization were from October 2015 to April 2016, and each patient intravenously received a single-dose of first generation cephalosporin 30 minutes before surgery, and one dose of antibiotics administered every 8 hours until 48 hours postoperation． Patients’ temperature, purulent drainage, pain or tenderness, local swelling, and wound healing were recorded and compared． Results: There was no postoperative infection happened in both groups. Conclusion: It is suggested that the first dose antibiotics given 30 mins before surgery and continued for two days is more economic, safe and effective.
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