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口腔颌面外科杂志
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口腔颌面外科杂志  2017, Vol. 27 Issue (4): 285-289    DOI: doi: 10.3969/j.issn.1005-4979.2017.04.013
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纤毛转运蛋白对骨发育影响的研究进展
李功臣,  孙瑶
上海牙组织修复与再生工程技术研究中心,同济大学口腔医学院·同济大学附属口腔医院口腔种植科,上海   20072
Recent Advances on Intraflagellar Transport Proteins in Bone
 LI  Gong-Chen,   Sun-Yao
Department of Implantology, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, Chin
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摘要 初级纤毛是突出于细胞表面的一种特殊细胞器,具有感受外界机械刺激和生物化学信号的功能。初级纤毛以微管为基础结构,外包被纤毛膜,内侧通过过渡区与细胞质相连接。纤毛内运输指纤毛转运蛋白在纤毛内携带信号分子进行的正向或逆向运输,是维持纤毛结构稳定和细胞信号传递的重要组成部分。纤毛转运蛋白的结构或功能改变,会导致人体多器官病变及功能紊乱。本文对纤毛转运蛋白的种类及其异常导致的硬组织相关疾病研究进展作一综述。
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李功臣
孙瑶
关键词初级纤毛;     纤毛内运输;     纤毛转运蛋白;     纤毛病     
Abstract: Primary cilia are the cellular organelles projecting from the cell surface to sense and transduce signaling. They contain microtubule-based (MT-based) internal structures , are covered with ciliary membrane and are connected with the cytoplasm by the transition zone. Intraflagellar transport(IFT), a bidirectional transport system, operated by IFT proteins and motors are indispensable for cilia structural stability and cell signaling. Those human diseases with primary cilia malfunction caused by the defect of IFT proteins are called ciliopathies. In this review, we describe the understanding of IFT proteins and its relationship to bone and tooth related ciliopathies.
Key words primary cilia   intraflagellar transport (IFT)   IFT proteins   ciliopathies   
基金资助:

国家自然基金(81470715);上海市卫生系统优秀学科带头人计划课题(2017BR009);国家重点研发计划(2016YFC1102705);国家自然基金面上项目(81771043)

通讯作者: 孙瑶,教授.      E-mail: E-mail: yaosun@tongji.edu.cn
作者简介: 李功臣(1988—),男,山东人,博士研究生. E-mail: ligongchen920@163.com.
引用本文:   
李功臣, 孙瑶. 纤毛转运蛋白对骨发育影响的研究进展[J]. 口腔颌面外科杂志, 2017, 27(4): 285-289.
LI Gong-Chen, Sun-Yao. Recent Advances on Intraflagellar Transport Proteins in Bone[J]. Journal of Oral and Maxillofacial Surgery, 2017, 27(4): 285-289.
 
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